Isotopically Labeled Compounds
Medchemexpress LLC Oxolinic acid-d5 | 1189890-98-9 | 98.0% | 1 MG
Oxolinic acid-d5 is the deuterium-labeled form of Oxolinic acid, an antibiotic effective against both Gram-negative and Gram-positive bacteria. It is used in research for acute and chronic urinary tract infections. This compound functions as a DNA/RNA synthesis inhibitor and a dopamine uptake inhibitor, stimulating locomotor effects in mice. It is intended for research use only.
- Can be used as a tracer
- Functions as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS
- Effective against Gram-negative and Gram-positive bacteria
- Inhibits DNA/RNA synthesis
- Acts as a dopamine uptake inhibitor
- Stimulates locomotor effects in mice
Medchemexpress LLC Biotin-d2-1 | 1217481-41-8 | 99.65% | 5 MG
Biotin-d2-1 is the deuterium labeled Biotin. Biotin is an enzyme co-factor present in minute amounts in every living cell.
- This compound can be used as a tracer.
- This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
- Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process.
- Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs.
Medchemexpress LLC Biotin-d2 | 58-85-5 | 98.5% | 1 MG
Biotin-d2 is the deuterium labeled Biotin. Biotin is an enzyme co-factor present in minute amounts in every living cell. Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs.
- Can be used as a tracer.
- Can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Medchemexpress LLC Biotin-d2 | 58-85-5 | 98.5% | 5 MG
Biotin-d2 is the deuterium labeled Biotin, an enzyme co-factor found in minute amounts in every living cell. This product is for research use only and is not intended for patient use.
- This compound can be utilized as a tracer.
- It serves as an internal standard for quantitative analysis using techniques such as NMR, GC-MS, or LC-MS.
- The incorporation of stable heavy isotopes like hydrogen and carbon into drug molecules, as seen with deuterium, is primarily for quantitation during drug development and has shown potential in influencing the pharmacokinetic and metabolic profiles of drugs.
Medchemexpress LLC Octopamine-d3 | 111988-19-3 | 99.5% | 1 MG
Octopamine-d3 is a deuterium labeled form of Octopamine, intended for research use only. This white to off-white solid can be used as a tracer or as an internal standard for quantitative analysis.
- Deuterium labeled Octopamine
- Used as a tracer
- Used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS
- Deuteration can impact pharmacokinetic and metabolic profiles of drugs
- Appears as a white to off-white solid
Medchemexpress LLC Acetamiprid-d3 | 1353869-35-8 | 99.9% | 1 MG
Acetamiprid-d3 is the deuterium labeled Acetamiprid. Acetamiprid is a neonicotinoid insecticide and a nAChR agonist.
- Can be used as a tracer.
- Can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
- Deuteration, the incorporation of stable heavy isotopes into drug molecules, has the potential to affect the pharmacokinetic and metabolic profiles of drugs.
Medchemexpress LLC Lercanidipine-d3 hydrochloride | 1189954-18-4 | 98.14% | 1 MG
Lercanidipine-d3 hydrochloride is the deuterium-labeled form of Lercanidipine, a lipophilic third-generation dihydropyridine-calcium channel blocker (DHP-CCB). It offers long-lasting antihypertensive action and reno-protective effects. Stable heavy isotopes of hydrogen, carbon, and other elements are incorporated into drug molecules primarily as tracers for quantitation during drug development. Deuteration can impact the pharmacokinetic and metabolic profiles of drugs.
- Functions as a tracer
- Can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS
Medchemexpress LLC Atorvastatin-d5 (sodium) | 222412-87-5 | 96.95% | 1 MG
Atorvastatin-d5 (sodium) is a deuterium-labeled Atorvastatin sodium. It acts as an orally active HMG-CoA reductase inhibitor, effectively decreasing blood lipids. This compound also inhibits human SV-SMC proliferation and invasion with IC50s of 0.39 μM and 2.39 μM respectively. Deuteration, the incorporation of stable heavy isotopes, can influence the pharmacokinetic and metabolic profiles of drugs.
- Can be used as a tracer
- Serves as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS
- Effectively decreases blood lipids
- Inhibits human SV-SMC proliferation and invasion
Medchemexpress LLC Xylometazoline-d4 hydrochloride | 1218-35-5 | 1 MG
Xylometazoline-d4 hydrochloride is a deuterated form of Xylometazoline hydrochloride (HY-B0475). Xylometazoline hydrochloride acts as an α-adrenergic receptor agonist with a Ki ranging from 0.05 to 1.7 μM. It is known for its ability to constrict nasal blood vessels and consequently increase nasal airflow, making it suitable for research concerning nose stuffiness and runny nose.
- This compound serves as a tracer.
- It can be utilized as an internal standard for quantitative analysis through methods like NMR, GC-MS, or LC-MS.
- Stable heavy isotopes, such as deuterium, are incorporated into drug molecules primarily for quantitation during the drug development process.
- Deuteration can impact the pharmacokinetic and metabolic profiles of drugs.
Medchemexpress LLC Norethindrone-d6 | 2376036-05-2 | 99.9% | 1 MG
Norethindrone-d6 is a deuterium-labeled version of Norethindrone, a female progestin approved by the FDA for treating endometriosis, uterine bleeding caused by abnormal hormone levels, and secondary amenorrhea. It is also a click chemistry reagent, containing an Alkyne group that can participate in copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
- Can be used as a tracer.
- Can be used as an internal standard for quantitative analysis by techniques such as NMR, GC-MS, or LC-MS.
- Stable heavy isotopes incorporated into drug molecules can act as tracers for quantitation during drug development.
- Deuteration has the potential to influence the pharmacokinetic and metabolic profiles of drugs.
Medchemexpress LLC Estriol-d2 | 53866-32-3 | 98.5% | 1 MG
Estriol-d2 is the deuterium labeled form of Estriol. It acts as an antagonist of the G-protein coupled estrogen receptor in estrogen receptor-negative breast cancer cells. This compound is suitable for use as a tracer and as an internal standard for quantitative analysis by techniques such as NMR, GC-MS, or LC-MS.
- Can be used as a tracer
- Functions as an internal standard for quantitative analysis (NMR, GC-MS, LC-MS)
- Deuterium labeled Estriol
- Antagonist of G-protein coupled estrogen receptor
- Molecular formula: C18H22D2O3
- Molecular weight: 290.39
- Purity: 98.47%
- Appearance: Solid, white to off-white
Medchemexpress LLC Penicillin V-d5 | 1356837-87-0 | 99.5% | 1 MG
Penicillin V-d5 (Phenoxymethylpenicillin-d5) is the deuterium-labeled form of Penicillin V, an orally active antibiotic that inhibits the growth of Streptococci, C. difficile, and S. aureus. It is utilized in research for conditions such as otitis, sinusitis, pharyngitis, and tonsillitis.
- Deuterium-labeled Penicillin V for quantitative analysis.
- Inhibits the growth of Streptococci, C. difficile, and S. aureus.
- Suitable for research on otitis, sinusitis, pharyngitis, and tonsillitis.
- Can be used as a tracer.
- Can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
- Deuteration can influence pharmacokinetic and metabolic profiles of drugs.
Medchemexpress LLC Spironolactone-d7 | 100.0% | 1 MG
Spironolactone-d7 is the deuterium-labeled version of Spironolactone, an orally active aldosterone mineralocorticoid receptor antagonist with an IC50 of 24 nM. It also acts as a potent antagonist of the androgen receptor with an IC50 of 77 nM and promotes autophagy in podocytes.
- Used as a tracer.
- Used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
- Deuteration has the potential to influence the pharmacokinetic and metabolic profiles of drugs.
- Intended for research use only.
Medchemexpress LLC Sulfamerazine-d4 | 1020719-84-9 | MFCD03425631 | 99.00% | 5 MG
Sulfamerazine-d4 is a deuterium-labeled variant of Sulfamerazine, which is classified as a sulfonamide antibacterial. Its mechanism of action involves inhibiting the bacterial synthesis of dihydrofolic acid. This is achieved by competing with para-aminobenzoic acid (PABA) for binding to dihydropteroate synthesizes.
- Deuterium labeled
- Internal standard
- Antibacterial properties
Medchemexpress LLC Flumequine-13C3 | 1185049-09-5 | 1 MG
Flumequine-13C3 is the 13C3 labeled Flumequine. It is a quinolone antibiotic that acts as a topoisomerase II inhibitor, with an IC50 of 15 μM (3.92 μg/mL).
- Can be used as a tracer
- Can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS
- Applicable in isotope-labeled compounds research
- Suitable for metabolic flux analysis
- Used in therapeutic drug monitoring